Acetaminophen and Butalbital side Effects

If you experience any of the following serious side effects, stop taking acetaminophen and butalbital and seek emergency medical attention:

Why Do I Have Headaches

Why Do I Have Headaches


  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue); or
  • blood problems (easy or unusual bleeding or bruising).
These side effects are very rare and are not likely to occur during proper treatment with acetaminophen and butalbital.
Other, less serious side effects may be more likely to occur. Continue to take acetaminophen and butalbital and talk to your doctor if you experience :
  • dry mouth;
  • nausea, vomiting, abdominal pain, or decreased appetite;
  • dizziness, tiredness, or lightheadedness;
  • drowsiness;
  • confusion;
  • agitation, irritability, or excitability;
  • rash or itching;
  • feeling of intoxication;
  • shortness of breath;
  • nervousness or anxiety; or
  • headache.
Butalbital may be habit forming.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What's A Headache

What's A Headache

What other drugs will affect acetaminophen and butalbital ?
Do not take acetaminophen and butalbital if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.
Acetaminophen and butalbital may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), other pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.
Many other medicines contain acetaminophen, especially over-the-counter pain, fever, cold, and allergy medications. Too much acetaminophen can be very dangerous.
Drugs other than those listed here may also interact with acetaminophen and butalbital. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?
  • Your pharmacist has additional information about acetaminophen and butalbital written for health professionals that you may read.
What does my medication look like ?
Acetaminophen and butalbital is available with a prescription under several brand and generic names. Ask your pharmacist any questions you have about this medication especially if it is new to you.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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